Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle

doi:10.1152/physiolgenomics.90211.2008

Article

Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle

17 Jun 2008

Abstract excerpt

In this study we have identified the target genes of sterol regulatory element binding protein (SREBP)-1a and SREBP-1c in primary cultures of human skeletal muscle cells, using adenoviral vectors expressing the mature nuclear form of human SREBP-1a or SREBP-1c combined with oligonucleotide microarrays. Overexpression of SREBP-1a led to significant changes in the expression of 1,315 genes (655 upregulated and 660...

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