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Article

Transcriptional profiling of Wnt3a mutants identifies Sp transcription factors as essential effectors of the Wnt/β-catenin pathway in neuromesodermal stem cells.

PloS one - 1 Jan 2014

Dunty William C, Kennedy Mark W L, Chalamalasetty Ravindra B, Campbell Kenneth, Yamaguchi Terry P

Abstract excerpt

Neuromesodermal (NM) stem cells reside in the primitive streak (PS) of gastrulating vertebrate embryos and generate precursors of the spinal cord and musculoskeletal system. Although Wnt3a/β-catenin signaling is crucial for NM stem cell maintenance and differentiation, few key transcriptional effectors have been identified. Through a concerted transcriptional profiling and genetic approach we have determined that...

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Identifiers

PMID: 24475213
DOI: 10.1371/journal.pone.0087018
PMCID: PMC3901714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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