Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.

doi:10.1101/gad.12.20.3156

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.

Genes & development - 15 Oct 1998

Min H, Danilenko D M, Scully S A, Bolon B, Ring B D, Tarpley J E, DeRose M, Simonet W S

Abstract excerpt

Fgf-10-deficient mice (Fgf-10(-/-)) were generated to determine the role(s) of Fgf-10 in vertebrate development. Limb bud initiation was abolished in Fgf-10(-/-) mice. Strikingly, Fgf-10(-/-) fetuses continued to develop until birth, despite the complete absence of both fore- and hindlimbs. Fgf-1...

Topics

Animals
Animals, Newborn
Drosophila
Drosophila Proteins
Female
Fibroblast Growth Factor 10
Fibroblast Growth Factors
Genes, Lethal
Insect Proteins
Limb Deformities, Congenital
Lung
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 9784490
DOI: 10.1101/gad.12.20.3156
PMCID: PMC317210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9784490-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics