Article
Common promoter C516T polymorphism in the ApoB gene is an independent predictor of carotid atherosclerotic disease in subjects presenting a broad range of plasma cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2004
Sposito Andrei C, Gonbert Sophie, Turpin Gerard, Chapman M John, Thillet Joëlle
Abstract excerpt
OBJECTIVE: A common polymorphism in the promoter of the apolipoprotein B (apoB) gene, a C to T change at position -516, increases the transcription rate of apoB, resulting in elevated circulating levels of low-density lipoprotein (LDL) cholesterol. METHODS AND RESULTS: We tested the hypothesis that carriers of the -516T allele, who may display consistent elevation in plasma cholesterol over their lifetime, may...
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