Article
Genetically elevated apolipoprotein A-I, high-density lipoprotein cholesterol levels, and risk of ischemic heart disease.
The Journal of clinical endocrinology and metabolism - 1 Dec 2010
Haase Christiane L, Tybjærg-Hansen Anne, Grande Peer, Frikke-Schmidt Ruth
Abstract excerpt
CONTEXT: Epidemiologically, levels of high-density lipoprotein (HDL) cholesterol and its major protein constituent, apolipoprotein A-I (apoA-I), are inversely related to risk of ischemic heart disease (IHD). OBJECTIVE: We tested whether common genetic variation in the apolipoprotein A1 gene (APOA1) contributes to apoA-I and HDL cholesterol levels and risk of IHD in the general population. DESIGN: We resequenced...
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