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Article

Genotypic effect of the -565C>T polymorphism in the ABCA1 gene promoter on ABCA1 expression and severity of atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2005

Kyriakou Theodosios, Hodgkinson Conrad, Pontefract David E, Iyengar Srikanth, Howell W Martin, Wong Yuk-ki, Eriksson Per, Ye Shu

Abstract excerpt

OBJECTIVE: Loss-of-function mutations of the ATP-binding cassette transporter A1 (ABCA1) gene cause Tangier disease, a rare genetic disorder with accumulation of lipid-laden macrophages and increased risk of atherosclerosis. Common variants of this gene may be a genetic factor for atherosclerosis...

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Source

Identifiers

PMID: 15528481
DOI: 10.1161/01.ATV.0000149379.72018.20

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15528481-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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