Article
Common and rare alleles in apolipoprotein B contribute to plasma levels of low-density lipoprotein cholesterol in the general population.
The Journal of clinical endocrinology and metabolism - 1 Mar 2008
Benn Marianne, Stene Maria C A, Nordestgaard Børge G, Jensen Gorm B, Steffensen Rolf, Tybjaerg-Hansen Anne
Abstract excerpt
CONTEXT: We have previously shown that rare mutations in the apolipoprotein B gene (APOB) may result in not only severe hypercholesterolemia and ischemic heart disease but also hypocholesterolemia. Despite this, common single-nucleotide polymorphisms (SNPs) in APOB have not convincingly been demonstrated to affect low-density lipoprotein (LDL) cholesterol levels. OBJECTIVE: We tested the hypothesis that...
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