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Article

A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease risk.

Journal of lipid research - 1 Mar 2008

Crawford Dana C, Nord Alex S, Badzioch Michael D, Ranchalis Jane, McKinstry Laura A, Ahearn Magdalena, Bertucci Caterina, Shephard Cynthia, Wong Michelle, Rieder Mark J, Schellenberg Gerard D, Nickerson Deborah A, Heagerty Patrick J, Wijsman Ellen M, Jarvik Gail P

Abstract excerpt

The genetic factors associated with carotid artery disease (CAAD) are not fully known. Because of its role in lipid metabolism, we hypothesized that common genetic variation in the very low density lipoprotein receptor (VLDLR) gene is associated with severe CAAD (>80% stenosis), body mass index (BMI), and lipid traits in humans. VLDLR was resequenced for variation discovery in 92 subjects, and single nucleotide...

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Source

Identifiers

PMID: 18056683
DOI: 10.1194/jlr.M700409-JLR200

Genes

VLDLR
APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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