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Article

Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process.

Molecular and cellular biology - 1 Feb 2009

Tonoki Ayako, Kuranaga Erina, Tomioka Takeyasu, Hamazaki Jun, Murata Shigeo, Tanaka Keiji, Miura Masayuki

Abstract excerpt

The intracellular accumulation of unfolded or misfolded proteins is believed to contribute to aging and age-related neurodegenerative diseases. However, the links between age-dependent proteotoxicity and cellular protein degradation systems remain poorly understood. Here, we show that 26S proteasome activity and abundance attenuate with age, which is associated with the impaired assembly of the 26S proteasome...

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Identifiers

PMID: 19075009
DOI: 10.1128/MCB.01227-08
PMCID: PMC2643801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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