Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of Rpn4-Induced Proteasome Expression in Saccharomyces cerevisiae Reduces Cell Viability Under Stressed Conditions

3 Oct 2008

Abstract excerpt

The proteasome homeostasis in Saccharomyces cerevisiae is regulated by a negative feedback circuit in which the transcription activator Rpn4 upregulates the proteasome genes and is rapidly degraded by the assembled proteasome. Previous studies have shown that rpn4Delta cells are sensitive to a variety of stresses. However, the contribution of the loss of Rpn4-induced proteasome expression to the rpn4Delta...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Endoplasmic Reticulum Stress and Disease
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18832351
DOI: 10.1534/genetics.108.094524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of Rpn4-Induced Proteasome Expression in Saccharomyces cerevisiae Reduces Cell Viability Under Stressed ConditionsPMID 18832351Read ↗

Integrity of the Saccharomyces cerevisiae Rpn11 protein is critical for formation of proteasome storage granules (PSG) and survival in stationary phase.Semantic proximity Read ↗

Homeostatic regulation of the proteasome via an Rpn4-dependent feedback circuit.Semantic proximity Read ↗

Proteasome mutants, pre4-2 and ump1-2, suppress the essential function but not the mitochondrial RNase P function of the Saccharomyces cerevisiae gene RPM2.Semantic proximity Read ↗

Yeast Rpn4 Links the Proteasome and DNA Repair via RAD52 Regulation.Semantic proximity Read ↗

Deletion of proteasomal subunit S5a/Rpn10/p54 causes lethality, multiple mitotic defects and overexpression of proteasomal genes in Drosophila melanogaster.Semantic proximity Read ↗

Proteasome subunit α1 overexpression preferentially drives canonical proteasome biogenesis and enhances stress tolerance in yeastSemantic proximity Read ↗

Mutations in PRG1, a yeast proteasome-related gene, cause defects in nuclear division and are suppressed by deletion of a mitotic cyclin gene.Semantic proximity Read ↗

Impaired proteasome function rescues thermosensitivity of yeast cells lacking the coatomer subunit epsilon-COP.Semantic proximity Read ↗

Proteasome disassembly and downregulation is correlated with viability during stationary phase.Semantic proximity Read ↗

Rpn6p, a proteasome subunit from Saccharomyces cerevisiae, is essential for the assembly and activity of the 26 S proteasome.Semantic proximity Read ↗

Quantitative analysis of the ubiquitin-proteasome system under proteolytic and folding stressorsSemantic proximity Read ↗

An Inducible Chaperone Adapts Proteasome Assembly to StressSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.