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Article

Loss of flight and associated neuronal rhythmicity in inositol 1,4,5-trisphosphate receptor mutants of Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Sept 2004

Banerjee Santanu, Lee Jisue, Venkatesh K, Wu Chun-Fang, Hasan Gaiti

Abstract excerpt

Coordinated flight in winged insects requires rhythmic activity of the underlying neural circuit. Here, we show that Drosophila mutants for the inositol 1,4,5-trisphosphate (InsP(3)) receptor gene (itpr) are flightless. Electrophysiological recordings from thoracic indirect flight muscles show increased spontaneous firing accompanied by a loss of rhythmic flight activity patterns normally generated in response to...

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Identifiers

PMID: 15356199
DOI: 10.1523/JNEUROSCI.0656-04.2004
PMCID: PMC1289272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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