Functional complementation of Drosophila itpr mutants by rat Itpr1.

doi:10.3109/01677063.2012.697501

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Article

Functional complementation of Drosophila itpr mutants by rat Itpr1.

Journal of neurogenetics - 1 Sept 2012

Chakraborty Sumita, Hasan Gaiti

Abstract excerpt

The Drosophila inositol 1,4,5-trisphosphate receptor (IP(3)R) and mammalian type-1 IP(3)Rs have 57-60% sequence similarity and share major domain homology with each other. Mutants in the single Drosophila IP(3)R gene, itpr, and Itpr1 knockout mice both exhibit lethality and defects in motor coordination. Here the authors show that the rat type-1 IP(3)R, which is the major neuronal isoform, when expressed in the...

Topics

Animals
Animals, Genetically Modified
Calcium
Cells, Cultured
Cytosol
Drosophila
Drosophila Proteins
Flight, Animal
Gene Expression Regulation
Genetic Therapy
Inositol 1,4,5-Trisphosphate Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Larva

Movement Disorders

Mutation

Neurons

Physical Stimulation

Rats

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 22817477
DOI: 10.3109/01677063.2012.697501

Genes

ITPR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22817477-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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