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Article

Inositol 1,4,5-trisphosphate receptor and dSTIM function in Drosophila insulin-producing neurons regulates systemic intracellular calcium homeostasis and flight.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Jan 2010

Agrawal Neha, Venkiteswaran Gayatri, Sadaf Sufia, Padmanabhan Nisha, Banerjee Santanu, Hasan Gaiti

Abstract excerpt

Calcium (Ca(2+)) signaling is known to regulate the development, maintenance and modulation of activity in neuronal circuits that underlie organismal behavior. In Drosophila, intracellular Ca(2+) signaling by the inositol 1,4,5-trisphosphate receptor and the store-operated channel (dOrai) regulates the formation and function of neuronal circuits that control flight. Here, we show that restoring InsP(3)R activity...

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Identifiers

PMID: 20107057
DOI: 10.1523/JNEUROSCI.3668-09.2010
PMCID: PMC6633787

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