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Article

Effects of serotonin transporter promoter polymorphisms on serotonin function.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2004

Smith Gwenn S, Lotrich Francis E, Malhotra Anil K, Lee Annette T, Ma Yilong, Kramer Elisse, Gregersen Peter K, Eidelberg David, Pollock Bruce G

Abstract excerpt

The serotonin transporter promoter polymorphism (5-HTTLPR) has been associated with vulnerability to stress-induced depressive symptoms and with the speed and rate of response to antidepressant treatment. The goal of the present study was to evaluate the association between the 5-HTTLPR and the functional response of the serotonin system as measured by the neuroendocrine and cerebral metabolic response to...

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PMID: 15354180
DOI: 10.1038/sj.npp.1300552

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