Article
Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression.
Archives of general psychiatry - 1 Jul 2007
Hu Xian-Zhang, Rush A John, Charney Dennis, Wilson Alexander F, Sorant Alexa J M, Papanicolaou George J, Fava Maurizio, Trivedi Madhukar H, Wisniewski Stephen R, Laje Gonzalo, Paddock Silvia, McMahon Francis J, Manji Husseini, Lipsky Robert H
Abstract excerpt
CONTEXT: The HTTLPR, a functional polymorphism of the serotonin transporter gene solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4), promoter, affects transcription and may be involved in antidepressant drug treatment outcome, although response rates with antidepressants can be lower in patients who experience adverse effects. OBJECTIVE: To test the hypothesis that HTTLPR is...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Ambulatory Care
- Citalopram
- Depressive Disorder, Major
- Female
- Genotype
- Humans