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Article

Serotonin transporter (5-HTT) promoter genotype may influence the prolactin response to clomipramine.

Psychopharmacology - 1 May 2000

Whale R, Quested D J, Laver D, Harrison P J, Cowen P J

Abstract excerpt

RATIONALE: A 44-base-pair insertion/deletion polymorphism in the promoter region of the human serotonin (5-HT) transporter (5-HTT) gene gives rise to a bi-allelic polymorphism designated long (l) and short (s). The s variant is associated with a lower expression of 5-HTT sites and a reduced efficiency of 5-HT reuptake. OBJECTIVE: The aim of the present study was to determine whether the increase in brain 5-HT...

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Identifiers

PMID: 10867985
DOI: 10.1007/s002130000432

Genes

HTT

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