Article
A novel real-time PCR assay for quantitative analysis of methylated alleles (QAMA): analysis of the retinoblastoma locus.
Nucleic acids research - 7 Sept 2004
Zeschnigk Michael, Böhringer Stefan, Price Elizabeth Ann, Onadim Zerrin, Masshöfer Lars, Lohmann Dietmar R
Abstract excerpt
Altered methylation patterns have been found to play a role in developmental disorders, cancer and aging. Increasingly, changes in DNA methylation are used as molecular markers of disease. Therefore, there is a need for reliable and easy to use techniques to detect and measure DNA methylation in research and routine diagnostics. We have established a novel quantitative analysis of methylated alleles (QAMA) which...
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