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Article

Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation.

The Journal of experimental medicine - 6 Sept 2004

Schuringa Jan Jacob, Chung Ki Young, Morrone Giovanni, Moore Malcolm A S

Abstract excerpt

Activation of the transcription factor signal transducer and activator of transcription (STAT)5 is involved in various aspects of hematopoiesis, affecting cell proliferation, differentiation, and cell survival. Constitutive activation of STAT5 has also been associated with leukemic transformation. We overexpressed the constitutively active mutant STAT5A(1*6) in human cord blood CD34+ cells and evaluated the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15353555
DOI: 10.1084/jem.20041024
PMCID: PMC2212750

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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