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Article

Identification of HIF2α as an important STAT5 target gene in human hematopoietic stem cells

24 Jan 2011

Abstract excerpt

The transcription factor signal transducer and activator of transcription 5 (STAT5) fulfills essential roles in self-renewal in mouse and human hematopoietic stem cells (HSCs), and its persistent activation contributes to leukemic transformation, although little molecular insight into the underlying mechanisms has been obtained. In the present study, we show that STAT5 can impose long-term expansion exclusively...

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Identifiers

PMID: 21263150
DOI: 10.1182/blood-2010-08-303669

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