Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood–derived CD34+ cells

16 Dec 2002

Abstract excerpt

Signal transducers and activators of transcription (STATs) have been reported to play a critical role in the differentiation of several myeloid cell lines, although the importance of STATs in the differentiation of primary human hematopoietic cells remains to be established. Terminal eosinophil differentiation is induced by interleukin-5 (IL-5), which has also been demonstrated to activate STAT5. We have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to IL-33, ST2, and ILC Pathways
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12393707
DOI: 10.1182/blood-2002-03-0740

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood–derived CD34+ cellsPMID 12393707Read ↗

Enforced activation of STAT5A facilitates the generation of embryonic stem-derived hematopoietic stem cells that contribute to hematopoiesis in vivo.Semantic proximity Read ↗

Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation.Semantic proximity Read ↗

Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.Semantic proximity Read ↗

The STAT5–GATA2 Pathway Is Critical in Basophil and Mast Cell Differentiation and MaintenanceSemantic proximity Read ↗

Identification of HIF2α as an important STAT5 target gene in human hematopoietic stem cellsSemantic proximity Read ↗

Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis.Semantic proximity Read ↗

Human C/EBP-ϵ activator and repressor isoforms differentially reprogram myeloid lineage commitment and differentiationSemantic proximity Read ↗

Transcription factor and cytokine regulation of eosinophil lineage commitmentSemantic proximity Read ↗

A STAT5B–CD9 axis determines self-renewal in hematopoietic and leukemic stem cellsSemantic proximity Read ↗

Conditional knockout mice demonstrate function of Klf5 as a myeloid transcription factorSemantic proximity Read ↗

Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes.Semantic proximity Read ↗

STAT5 Activation Is Critical for the Transformation Mediated by Myeloproliferative Disorder-associated JAK2 V617F MutantSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.