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Article

Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells.

Experimental hematology - 1 Apr 2007

Moore Malcolm A S, Dorn David C, Schuringa Jan Jacob, Chung Ki Young, Morrone Giovanni

Abstract excerpt

OBJECTIVE: To model human leukemogenesis by transduction of human hematopoietic stem cells (HSC) with genes associated with leukemia and expressed in leukemic stem cells. METHODS: Constitutive activation of Flt3 (Flt3-ITD) has been reported in 25 to 30% of patients with acute myeloid leukemia (AML). Retroviral vectors expressing constitutively activated Flt3 and STAT5A were used to transduce human cord blood...

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Share to ADP-ribosyl Cyclase 1
Share to Antigens, CD34

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Erythropoiesis

Share to Gene Expression Regulation, Leukemic

Share to Myelopoiesis

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Source

Identifiers

PMID: 17379095
DOI: 10.1016/j.exphem.2007.01.018

Genes

HLF
HOXA5
HOXA9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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