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Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition

7 Oct 2024

Abstract excerpt

ABSTRACT: Adult hematopoietic stem cells (HSCs) are responsible for the lifelong production of blood and immune cells, a process regulated by extracellular cues, including cytokines. Many cytokines signal through the conserved Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway in which tyrosine-phosphorylated STATs (pSTATs) function as transcription factors. STAT5 is a pivotal...

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PMID: 39374575
DOI: 10.1182/bloodadvances.2024014046

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