Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis.

The Journal of experimental medicine - 4 Jul 2005

Kato Yuko, Iwama Atsushi, Tadokoro Yuko, Shimoda Kazuya, Minoguchi Mayu, Akira Shizuo, Tanaka Minoru, Miyajima Atsushi, Kitamura Toshio, Nakauchi Hiromitsu

Abstract excerpt

Although the concept of a leukemic stem cell system has recently been well accepted, its nature and the underlying molecular mechanisms remain obscure. Constitutive activation of signal transducers and activators of transcription 3 (STAT3) and STAT5 is frequently detected in various hematopoietic tumors. To evaluate their role in normal and leukemic stem cells, we took advantage of constitutively active STAT...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoiesis
Share to Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Experimental

Share to Milk Proteins

Share to Myeloproliferative Disorders

Share to Neoplastic Stem Cells

Share to STAT3 Transcription Factor

Share to STAT5 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 15998795
DOI: 10.1084/jem.20042541
PMCID: PMC2212906

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis.PMID 15998795Read ↗

Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation.Semantic proximity Read ↗

A STAT5B–CD9 axis determines self-renewal in hematopoietic and leukemic stem cellsSemantic proximity Read ↗

Maintenance of haematopoietic stem cells by JAK inhibition and increased tyrosine-unphosphorylated STAT5Semantic proximity Read ↗

Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibitionSemantic proximity Read ↗

Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis.Semantic proximity Read ↗

Dissecting Out a Rare Mutation, STAT: Features of STAT3-Mutant Myeloid Neoplasms.Semantic proximity Read ↗

STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromesSemantic proximity Read ↗

STAT signaling in the pathogenesis and treatment of myeloid malignanciesSemantic proximity Read ↗

Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewalSemantic proximity Read ↗

Cancer-Associated STAT3 Mutations Maintain ES Cell Self-Renewal Through Phosphorylation-Independent Mechanisms.Semantic proximity Read ↗

Maximal STAT5-Induced Proliferation and Self-Renewal at Intermediate STAT5 Activity LevelsSemantic proximity Read ↗

Enforced activation of STAT5A facilitates the generation of embryonic stem-derived hematopoietic stem cells that contribute to hematopoiesis in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.