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Maximal STAT5-Induced Proliferation and Self-Renewal at Intermediate STAT5 Activity Levels

9 Sept 2008

Abstract excerpt

The level of transcription factor activity critically regulates cell fate decisions, such as hematopoietic stem cell (HSC) self-renewal and differentiation. We introduced STAT5A transcriptional activity into human HSCs/progenitor cells in a dose-dependent manner by overexpression of a tamoxifen-inducible STAT5A(1*6)-estrogen receptor fusion protein. Induction of STAT5A activity in CD34(+) cells resulted in...

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PMID: 18779318
DOI: 10.1128/mcb.01025-08

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