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Article

Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest.

Biochemical and biophysical research communications - 30 Nov 1999

Fujimori F, Takahashi K, Uchida C, Uchida T

Abstract excerpt

The peptidyl prolil cis/trans isomerase Ess1/Pin1 is essential for mitosis progression in yeast cells and is hypothesized to perform the same role in mammalian cells. To investigate the function of Pin1 in mammalian cells, we created mice lacking Pin1. These mice underwent normal development. Alt...

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Source

Identifiers

PMID: 10600477
DOI: 10.1006/bbrc.1999.1736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10600477-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest.PMID 10600477Read ↗

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The Peptidyl-Prolyl Isomerase Pin1 Regulates Cytokinesis through Cep55Semantic proximity Read ↗

Oncogenic Hijacking of the PIN1 Signaling NetworkSemantic proximity Read ↗

Crosstalk of prolyl isomerases, Pin1/Ess1, and cyclophilin A.Semantic proximity Read ↗

The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins.Semantic proximity Read ↗

Differential Regulation of Cellular Senescence and Differentiation by Prolyl Isomerase Pin1 in Cardiac Progenitor CellsSemantic proximity Read ↗

The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery.Semantic proximity Read ↗

The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion.Semantic proximity Read ↗

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