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Article

Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest.

Biochemical and biophysical research communications - 30 Nov 1999

Fujimori F, Takahashi K, Uchida C, Uchida T

Abstract excerpt

The peptidyl prolil cis/trans isomerase Ess1/Pin1 is essential for mitosis progression in yeast cells and is hypothesized to perform the same role in mammalian cells. To investigate the function of Pin1 in mammalian cells, we created mice lacking Pin1. These mice underwent normal development. Although the embryonic Pin1-/- fibroblasts grew normally, they proved significantly deficient in their ability to restart...

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Identifiers

PMID: 10600477
DOI: 10.1006/bbrc.1999.1736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest.PMID 10600477Read ↗

A role for Pin1 in mammalian germ cell development and spermatogenesis.Semantic proximity Read ↗

Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes.Semantic proximity Read ↗

The Loss of PIN1 Deregulates Cyclin E and Sensitizes Mouse Embryo Fibroblasts to Genomic InstabilitySemantic proximity Read ↗

The role of the master cancer regulator Pin1 in the development and treatment of cancerSemantic proximity Read ↗

Phosphorylation-dependent proline isomerization catalyzed by Pin1 is essential for tumor cell survival and entry into mitosis.Semantic proximity Read ↗

The Peptidyl-Prolyl Isomerase Pin1 Regulates Cytokinesis through Cep55Semantic proximity Read ↗

Oncogenic Hijacking of the PIN1 Signaling NetworkSemantic proximity Read ↗

Crosstalk of prolyl isomerases, Pin1/Ess1, and cyclophilin A.Semantic proximity Read ↗

The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins.Semantic proximity Read ↗

Differential Regulation of Cellular Senescence and Differentiation by Prolyl Isomerase Pin1 in Cardiac Progenitor CellsSemantic proximity Read ↗

The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery.Semantic proximity Read ↗

The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion.Semantic proximity Read ↗

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