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The Peptidyl-Prolyl Isomerase Pin1 Regulates Cytokinesis through Cep55

1 Aug 2009

Abstract excerpt

Failure of cytokinesis results in tetraploidy and can increase the genomic instability frequently observed in cancer. The peptidyl-prolyl isomerase Pin1, which is deregulated in many tumors, regulates several processes, including cell cycle progression. Here, we show a novel role for Pin1 in cytokinesis. Pin1 knockout mouse embryonic fibroblasts show a cytokinesis delay, and depletion of Pin1 from HeLa cells also...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19638580
DOI: 10.1158/0008-5472.can-09-0825

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Related research

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Research trail→

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The Peptidyl-Prolyl Isomerase Pin1 Regulates Cytokinesis through Cep55PMID 19638580Read ↗

Cep55 stabilization is required for normal execution of cytokinesis.Semantic proximity Read ↗

The role of the master cancer regulator Pin1 in the development and treatment of cancerSemantic proximity Read ↗

The Loss of PIN1 Deregulates Cyclin E and Sensitizes Mouse Embryo Fibroblasts to Genomic InstabilitySemantic proximity Read ↗

Prolyl Isomerase Pin1 in Human Cancer: Function, Mechanism, and SignificanceSemantic proximity Read ↗

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Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function.Semantic proximity Read ↗

Pinning Down Signaling in the Immune System: The Role of the Peptidyl-Prolyl Isomerase Pin1 in Immune Cell FunctionSemantic proximity Read ↗

Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes.Semantic proximity Read ↗

A role for Pin1 in mammalian germ cell development and spermatogenesis.Semantic proximity Read ↗

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Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest.Semantic proximity Read ↗

Phosphorylation-dependent proline isomerization catalyzed by Pin1 is essential for tumor cell survival and entry into mitosis.Semantic proximity Read ↗

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