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Article

Association between GSK-3beta -50T/C polymorphism and personality and psychotic symptoms in mood disorders.

Psychiatry research - 15 Mar 2008

Serretti Alessandro, Benedetti Francesco, Mandelli Laura, Calati Raffaella, Caneva Barbara, Lorenzi Cristina, Fontana Valentina, Colombo Cristina, Smeraldi Enrico

Abstract excerpt

The exact role of the enzyme glycogen synthase kinase 3beta (GSK-3beta) in mood disorders is still unknown. GSK-3beta has been mapped to chromosome 3q13.3, a potential susceptibility locus for bipolar disorder. The -50T/C polymorphism, falling within the promoter region of the gene coding for GSK-3beta, was previously reported to be associated with age at onset, therapeutic response to lithium salts and total...

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Identifiers

PMID: 17976739
DOI: 10.1016/j.psychres.2007.06.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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