Article
RET polymorphisms in codons 769 and 836 are not associated with predisposition to medullary thyroid carcinoma.
Cancer detection and prevention - 1 Jan 2004
Wiench Małgorzata, Włoch Jan, Wygoda Zbigniew, Gubała Elzbieta, Oczko M, Pawlaczek A, Kula D, Lange D, Jarzab B
Abstract excerpt
The study was undertaken to verify whether the RET gene polymorphisms are associated with MTC in patients negative for germline mutations. Two hundred five patients with apparent sporadic MTC were subjected to genetic analysis of RET exons 10, 11, 13, 14, 16 and 22 RET germline mutation carriers were identified with 10.7% frequency. The frequency among 26 patients not older than 30 was 27%. In patients excluded...
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