Article
Genotype-phenotype correlations in hereditary medullary thyroid carcinoma: oncological features and biochemical properties.
The Journal of clinical endocrinology and metabolism - 1 Mar 2001
Machens A, Gimm O, Hinze R, Höppner W, Boehm B O, Dralle H
Abstract excerpt
In hereditary medullary thyroid carcinoma (MTC), few genotype-phenotype correlations have been established. RET genotypes (exons 10, 11, 13, and 14) of 63 patients with hereditary MTC (from November 1994 to October 1999) were correlated with age at diagnosis, sex, the TNM system, and basal calcitonin levels. Mutations in exons 10, 11, 13, and 14 were demonstrated in 22% (14 of 63), 54% (34 of 63), 21% (13 of 63),...
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