Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in the hypoxia inducible factor-1alpha gene (HIF1A) are associated with the renal cell carcinoma phenotype.

Cancer genetics and cytogenetics - 1 Sept 2004

Ollerenshaw Martin, Page Toby, Hammonds John, Demaine Andrew

Abstract excerpt

Hypoxia inducible factor 1 (HIF-1) is a key regulator of the genes involved in the cellular response to hypoxia. HIF consists of alpha and beta subunits, with the alpha subunit being degraded under normoxic conditions and stabilized under hypoxia. We investigated C1772T and G1790A polymorphisms in exon 12 of the HIF gene, which result in an amino acid change from proline 582 to serine and from alanine 588 to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Kidney Neoplasms

Share to Mutation, Missense

Share to Neoplasm Staging

Share to Reference Values

Source

Identifiers

PMID: 15350301
DOI: 10.1016/j.cancergencyto.2004.01.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in the hypoxia inducible factor-1alpha gene (HIF1A) are associated with the renal cell carcinoma phenotype.PMID 15350301Read ↗

The C1772T genetic polymorphism in human HIF-1alpha gene associates with expression of HIF-1alpha protein in breast cancer.Semantic proximity Read ↗

Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to androgen-independent prostate cancer.Semantic proximity Read ↗

Hypoxia and renal cell carcinoma: The influence of HIF1A+1772C/T functional genetic polymorphism on prognosis.Semantic proximity Read ↗

HIF1A gene polymorphisms and human diseases: Graphical review of 97 association studies.Semantic proximity Read ↗

Hypoxia-inducible factor-1α polymorphisms are associated with genetic aberrations in lung cancer.Semantic proximity Read ↗

Association of hypoxia-inducible factor 1-alpha gene polymorphisms and colorectal cancer prognosis.Semantic proximity Read ↗

Hypoxia-inducible factor-1α C1772T polymorphism and cancer risk: a meta-analysis including 18,334 subjects.Semantic proximity Read ↗

HIF-1α (1772C>T) polymorphism as marker for breast cancer development.Semantic proximity Read ↗

Hypoxia-inducible factor-1alpha gene polymorphisms and cancer risk: a meta-analysis.Semantic proximity Read ↗

VHL and HIF-1α: gene variations and prognosis in early-stage clear cell renal cell carcinoma.Semantic proximity Read ↗

Clinicopathological significance of hypoxia-inducible factor-1 alpha polymorphisms in cancers: evidence from a meta-analysis.Semantic proximity Read ↗

The association between hypoxia-inducible factor-1 α gene C1772T polymorphism and cancer risk: a meta-analysis of 37 case-control studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.