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Article

Association of Three HIF-1α Genotypes With Susceptibility and Severity of Chronic Kidney Disease.

Clinical and translational science - 1 Oct 2026

Aktar Hanifa, Ashena Shahrzad, Ardekani Mohammad Sanaei, Movafagh Shahrzad

Abstract excerpt

Hypoxic signaling is a critical factor in the pathogenesis of Chronic Kidney Disease (CKD). Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor that is highly expressed in the kidney and is associated with renal tubular hypoxic adaptation. Variation in the HIF-1α subunit gene has been associated with renal pathologies. This study investigated the association between three single-nucleotide polymorphisms...

Read the complete abstract on PubMed

Topics

Humans
Hypoxia-Inducible Factor 1, alpha Subunit
Female
Polymorphism, Single Nucleotide
Renal Insufficiency, Chronic
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Middle Aged

Severity of Illness Index

Case-Control Studies

Genotype

Aged

Adult

Genetic Association Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 42765744
DOI: 10.1111/cts.70731
PMCID: PMC13592220

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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