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Article

Hypoxia-inducible factor-1α polymorphisms are associated with genetic aberrations in lung cancer.

Respirology (Carlton, Vic.) - 1 Jul 2011

Putra Andika C, Tanimoto Keiji, Arifin Marina, Hiyama Keiko

Abstract excerpt

BACKGROUND AND OBJECTIVE: The transcription factor, hypoxia-inducible factor-1 (HIF-1), is a master regulator of hypoxia, including repression of DNA repair systems, resulting in genomic instability in cancer cells. The roles of the polymorphic HIF-1α variants, C1772T (P582S) and G1790A (A588T), which are known to enhance transcriptional activity, were evaluated in lung cancers. METHODS: HIF-1α polymorphisms were...

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Source

Identifiers

PMID: 21435097
DOI: 10.1111/j.1440-1843.2011.01972.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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