Hypoxia and renal cell carcinoma: The influence of HIF1A+1772C/T functional genetic polymorphism on prognosis.

doi:10.1016/j.urolonc.2017.04.002

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Article

Hypoxia and renal cell carcinoma: The influence of HIF1A+1772C/T functional genetic polymorphism on prognosis.

Urologic oncology - 1 Aug 2017

Ferreira Marta, Teixeira Ana, Maurício Joaquina, Lobo Francisco, Morais António, Medeiros Rui

Abstract excerpt

OBJECTIVES: Hypoxia-inducible factor (HIF-1) is a key regulator of the genes involved in the cellular response to hypoxia. Overexpression of HIF-1 has been implicated in the pathogenesis of renal cell carcinoma (RCC), and functional polymorphisms of the HIF1A gene may confer susceptibility to RCC. Our purpose was to assess the influence of HIF1A+1772C/T (rs11549465) polymorphism on RCC prognosis. MATERIAL AND...

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PMID: 28476527
DOI: 10.1016/j.urolonc.2017.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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