Article
Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine - 15 Dec 2004
DeMeo Dawn L, Celedón Juan C, Lange Christoph, Reilly John J, Chapman Harold A, Sylvia Jody S, Speizer Frank E, Weiss Scott T, Silverman Edwin K
Abstract excerpt
Familial aggregation of forced expiratory flow during the middle half of the FVC (FEF(25-75%)) and FEF(25-75%)/FVC has been observed in the Boston Early-Onset Chronic Obstructive Pulmonary Disease Study, but linkage results have not been reported for these phenotypes. An autosomal whole genome-wide linkage scan was performed in 72 pedigrees ascertained through a proband with severe, early-onset chronic...
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