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Article

Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease.

American journal of human genetics - 1 May 2002

Silverman Edwin K, Palmer Lyle J, Mosley Jonathan D, Barth Matthew, Senter Jody M, Brown Alison, Drazen Jeffrey M, Kwiatkowski David J, Chapman Harold A, Campbell Edward J, Province Michael A, Rao D C, Reilly John J, Ginns Leo C, Speizer Frank E, Weiss Scott T

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is a common, complex disease associated with substantial morbidity and mortality. COPD is defined by irreversible airflow obstruction; airflow obstruction is typically determined by reductions in quantitative spirometric indices, including forced expiratory volume at 1 s (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC). To identify genetic determinants...

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Identifiers

PMID: 11914989
DOI: 10.1086/340316
PMCID: PMC447597

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FEV

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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