Article
Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes.
Human molecular genetics - 15 Mar 2002
Silverman Edwin K, Mosley Jonathan D, Palmer Lyle J, Barth Matthew, Senter Jody M, Brown Alison, Drazen Jeffrey M, Kwiatkowski David J, Chapman Harold A, Campbell Edward J, Province Michael A, Rao D C, Reilly John J, Ginns Leo C, Speizer Frank E, Weiss Scott T
Abstract excerpt
Familial aggregation of chronic obstructive pulmonary disease (COPD) has been demonstrated, but linkage analysis of COPD-related phenotypes has not been reported previously. An autosomal 10 cM genome-wide scan of short tandem repeat (STR) polymorphic markers was analyzed for linkage to COPD-related phenotypes in 585 members of 72 pedigrees ascertained through severe, early-onset COPD probands without severe...
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