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Article

Differential roles of STAT3 in the initiation and growth of lung cancer.

Oncogene - 1 Jul 2015

Zhou Jingjiao, Qu Zhaoxia, Yan Shapei, Sun Fan, Whitsett Jeffrey A, Shapiro Steven D, Xiao Gutian

Abstract excerpt

Signal transducer and activator of transcription 3 (STAT3) is linked to multiple cancers, including pulmonary adenocarcinoma. However, the role of STAT3 in lung cancer pathogenesis has not been determined. Using lung epithelial-specific inducible knockout strategies, we demonstrate that STAT3 has contrasting roles in the initiation and growth of both chemically and genetically induced lung cancers. Selective...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25284582
DOI: 10.1038/onc.2014.318
PMCID: PMC4387125

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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