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Article

Essential Role of STAT3 Signaling in Hair Follicle Homeostasis

11 Nov 2021

Abstract excerpt

Dominant-negative mutations associated with signal transducer and activator of transcription 3 (STAT3) signaling, which controls epithelial proliferation in various tissues, lead to atopic dermatitis in hyper IgE syndrome. This dermatitis is thought to be attributed to defects in STAT3 signaling in type 17 helper T cell specification. However, the role of STAT3 signaling in skin epithelial cells remains unclear....

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PMID: 34867936
DOI: 10.3389/fimmu.2021.663177

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