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Article

Prevention of Tobacco Carcinogen-Induced Lung Tumor Development by a Novel STAT3 Decoy Inhibitor.

Cancer prevention research (Philadelphia, Pa.) - 1 Sept 2020

Njatcha Christian, Farooqui Mariya, Almotlak Abdulaziz A, Siegfried Jill M

Abstract excerpt

The STAT3 pathway is frequently overactive in non-small cell lung cancer (NSCLC), an often fatal disease with known risk factors including tobacco and chemical exposures. Whether STAT3 can be downmodulated to delay or prevent development of lung cancer resulting from an environmental exposure has not been previously tested. A circular oligonucleotide STAT3 decoy (CS3D) was used to treat mice previously exposed to...

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Identifiers

PMID: 32655003
DOI: 10.1158/1940-6207.CAPR-20-0033
PMCID: PMC7485626

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