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Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease.

Biochimica et biophysica acta - 1 Feb 2012

Reddy P Hemachandra, Shirendeb Ulziibat P

Abstract excerpt

Huntington's disease (HD) is a progressive, fatal neurodegenerative disease caused by expanded polyglutamine repeats in the HD gene. HD is characterized by chorea, seizures, involuntary movements, dystonia, cognitive decline, intellectual impairment and emotional disturbances. Research into mutant huntingtin (Htt) and mitochondria has found that mutant Htt interacts with the mitochondrial protein dynamin-related...

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Axonal Transport
Huntingtin Protein
Huntington Disease
Mitochondria
Nerve Tissue Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

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PMID: 22080977
DOI: 10.1016/j.bbadis.2011.10.016
PMCID: PMC3249480

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