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HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury

1 Sept 2022

Abstract excerpt

HTT (huntingtin) is a 350-kDa protein of unknown function. While HTT moves bidirectionally within axons and HTT loss/reduction causes axonal transport defects, the identity of cargo-containing vesicles that HTT helps move remain elusive. Previously, we found an axonal retrogradely moving HTT-Rab7 vesicle complex; however, its biological relevance is unclear. Using Drosophila genetics, in vivo microscopy, membrane...

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PMID: 36048753
DOI: 10.1080/15548627.2022.2119351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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