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Article

Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease.

Leukemia - 1 Jun 2024

Behrens Kira, Kauppi Maria, Viney Elizabeth M, Kueh Andrew J, Hyland Craig D, Willson Tracy A, Salleh Liam, de Graaf Carolyn A, Babon Jeffrey J, Herold Marco J, Nicola Nicos A, Alexander Warren S

Abstract excerpt

Thrombopoietin (Tpo), which binds to its specific receptor, the Mpl protein, is the major cytokine regulator of megakaryopoiesis and circulating platelet number. Tpo binding to Mpl triggers activation of Janus kinase 2 (Jak2) and phosphorylation of the receptor, as well as activation of several intracellular signalling cascades that mediate cellular responses. Three tyrosine (Y) residues in the C-terminal region...

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Identifiers

PMID: 38491305
DOI: 10.1038/s41375-024-02219-5
PMCID: PMC11147766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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