Article
Rapid determination of five probe drugs and their metabolites in human plasma and urine by liquid chromatography/tandem mass spectrometry: application to cytochrome P450 phenotyping studies.
Rapid communications in mass spectrometry : RCM - 1 Jan 2004
Yin Ophelia Q P, Lam Sherry S L, Lo Cindy M Y, Chow Moses S S
Abstract excerpt
A liquid chromatography/mass spectrometry method, for rapid determination of five cytochrome P450 (CYP) probe drugs and their relevant metabolites in human plasma and urine, is described. The five specific probe substrates/metabolites, caffeine/paraxanthine (CYP1A2), tolbutamide/4-hydroxytolbutam...
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