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Article

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy.

Science (New York, N.Y.) - 27 Aug 2004

Cuervo Ana Maria, Stefanis Leonidas, Fredenburg Ross, Lansbury Peter T, Sulzer David

Abstract excerpt

Aberrant alpha-synuclein degradation is implicated in Parkinson's disease pathogenesis because the protein accumulates in the Lewy inclusion bodies associated with the disease. Little is known, however, about the pathways by which wild-type alpha-synuclein is normally degraded. We found that wild-type alpha-synuclein was selectively translocated into lysosomes for degradation by the chaperone-mediated autophagy...

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Identifiers

PMID: 15333840
DOI: 10.1126/science.1101738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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