Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alpha-synuclein degradation by autophagic pathways: A potential key to Parkinson’s Disease pathogenesis

4 Aug 2008

Abstract excerpt

The neuronal protein alpha-synuclein is thought to be central in the pathogenesis of Parkinson's disease (PD). Excessive wild type alpha-synuclein levels can lead to PD in select familial cases and alpha-synuclein protein accumulation occurs in sporadic PD. Therefore, elucidation of the mechanisms that control alpha-synuclein levels is critical for PD pathogenesis and potential therapeutics. The subject of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Lysosomal Storage Disorders Research
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18708765
DOI: 10.4161/auto.6685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alpha-synuclein degradation by autophagic pathways: A potential key to Parkinson’s Disease pathogenesisPMID 18708765Read ↗

Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson’s DiseaseSemantic proximity Read ↗

Autophagy in α-Synucleinopathies—An Overstrained SystemSemantic proximity Read ↗

α-Synuclein impairs macroautophagy: implications for Parkinson’s diseaseSemantic proximity Read ↗

Lysosomal dysfunction in α-synuclein pathology: molecular mechanisms and therapeutic strategies.Semantic proximity Read ↗

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease.Semantic proximity Read ↗

Synaptojanin1 regulates lysosomal functions in ventral midbrain neuronsSemantic proximity Read ↗

Role of Chaperone-Mediated Autophagy Dysfunctions in the Pathogenesis of Parkinson’s DiseaseSemantic proximity Read ↗

Lysosomal dysfunction in neurodegenerationSemantic proximity Read ↗

Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s DiseaseSemantic proximity Read ↗

The Parkinson disease protein α-synuclein inhibits autophagySemantic proximity Read ↗

Alpha‐synuclein‐associated changes in PINK1‐PRKN‐mediated mitophagy are disease context dependentSemantic proximity Read ↗

Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy modelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.