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Article

Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols.

The Journal of biological chemistry - 5 Nov 2004

Anter Elad, Thomas Shane R, Schulz Eberhard, Shapira Oz M, Vita Joseph A, Keaney John F

Abstract excerpt

Black tea improves endothelial function in patients with coronary artery disease. We sought to determine the responsible components of black tea and elucidate the underlying cell signaling mechanisms. We exposed porcine aortic endothelial cells to components of black tea and found that the polyphenol fraction acutely enhanced nitric oxide bioactivity. This effect involved endothelial nitric-oxide synthase (eNOS)...

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Identifiers

PMID: 15333638
DOI: 10.1074/jbc.M405547200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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