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Article

Signaling by eNOS through a superoxide-dependent p42/44 mitogen-activated protein kinase pathway.

American journal of physiology. Cell physiology - 1 Aug 2001

Wang W, Wang S, Nishanian E V, Del Pilar Cintron A, Wesley R A, Danner R L

Abstract excerpt

Expression of endothelial nitric oxide synthase (eNOS) in transfected U-937 cells upregulates phorbol 12-myristate 13-acetate (PMA)-induced tumor necrosis factor-alpha (TNF-alpha) production through a superoxide (O(2)(-))-dependent mechanism. Because mitogen-activated protein kinases (MAPK) have been shown to participate in both reactive oxygen species signaling and TNF-alpha regulation, their possible role in...

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Identifiers

PMID: 11443053
DOI: 10.1152/ajpcell.2001.281.2.C544

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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