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Article

Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site.

The Journal of clinical investigation - 1 Nov 2001

Du X L, Edelstein D, Dimmeler S, Ju Q, Sui C, Brownlee M

Abstract excerpt

Endothelial nitric oxide synthase (eNOS) is activated by phosphorylation of serine 1177 by the protein kinase Akt/PKB. Since hyperglycemia-induced mitochondrial superoxide overproduction increases O-linked N-acetylglucosamine modification and decreases O-linked phosphorylation of the transcription factor Sp1, the effect of hyperglycemia and the hexosamine pathway on eNOS was evaluated. In bovine aortic...

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Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelium, Vascular

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Share to Nitric Oxide Synthase Type III

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Source

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Identifiers

PMID: 11696579
DOI: 10.1172/JCI11235
PMCID: PMC209429

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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