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Article

Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway.

Journal of vascular research - 1 Jan 2010

Tie Guodong, Yan Jinglian, Yang Yagai, Park Brian D, Messina Julia A, Raffai Robert L, Nowicki Philip T, Messina Louis M

Abstract excerpt

We tested the hypothesis that oxidized low-density lipoprotein (oxLDL)-induced inactivation of Akt within endothelial progenitor cells (EPCs) is mediated at the level of phosphoinositide 3-kinase (PI3K), specifically by nitrosylation of the p85 subunit of PI3K, and that this action is critical in provoking oxLDL-induced EPC apoptosis. Hypercholesterolemic ApoE null mice had a significant reduction of the...

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Identifiers

PMID: 20431300
DOI: 10.1159/000313879
PMCID: PMC2945270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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