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Article

Differential interleukin secretion by in vitro activated human CD45RA and CD45RO CD4+ T cell subsets.

Cellular immunology - 15 Apr 1992

Ferrer J M, Plaza A, Kreisler M, Díaz-Espada F

Abstract excerpt

The CD45RA and CD45RO isoforms have been reported to define complementary subsets among CD4+ T cells: CD45RA CD4+ T cells are considered "virgin T cells" and CD45RO "primed T cells." We investigated the secretion of lymphokines by human CD4+ CD45RO and CD4+ CD45RA T helper cells after mitogen stimulation. CD45RA and CD45RO CD4+ T cells were isolated by negative immunoselection using magnetic beads. CD45RO cells,...

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PMID: 1532537
DOI: 10.1016/0008-8749(92)90123-7

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